Natural Killer Cell Immunotherapy For Cancer

While chimeric antigen receptors cars have been used extensively to redirect the specificity of autologous t cells against hematological malignancies with striking clinical results studies of car modified natural killer nk cells have been largely preclinical.

Natural killer cell immunotherapy for cancer.

Natural killer cells plus immunotherapy for triple negative breast cancer. The immunotherapy that remains on the front burner is car t. Nk cells activity is controlled by the interaction of a wide range of receptors expressed on their surfaces with cell surface ligands. In this process t cells a type of white blood cell that are part of the body s immune system are extracted from a person s.

Cancer immunotherapy has been firmly established as a new milestone for cancer therapy with the development of multiple immune cells as therapeutic tools. Natural killer nk cells and cd8 cytotoxic t cells are two types of immune cells that can kill target cells through similar cytotoxic mechanisms. With the remarkable success of chimeric antigen receptor car engineered t car t cells for treating haematological malignancies there is a rapid growing interest in developing car engineered nk car nk cells for cancer therapy. The past several years have seen tremendous advances in the engineering of immune effector cells as therapy for cancer.

Nk cells can be targeted to kill with exquisite antigen specificity by antibody. Natural killer nk cells have evolved to complement t and b cells in host defense against pathogens and cancer. Now pcf funded investigator dr. Natural killer nk cells are crucial components of the innate immune system and play critical roles in host immunity against viral infections and cancer.

They recognize infected cells and tumors using a sophisticated array of activating costimulatory and inhibitory receptors that are expressed on nk cell subsets to create extensive functional diversity. Meaning the cancer cells lack estrogen or progesterone receptors and make very little of the. Natural killer nk cells are innate immune cells endowed with potent cytolytic activity against tumors and meanwhile act as regulatory cells for the immune system. These cells are like beat cops on patrol traveling around the body to look for and kill cells infected with a virus bacteria and cancer cells.

Opposite signals delivered by inhibitory and activating receptors tightly regulate nk cells. With the remarkable success of chimeric antigen receptor car engineered t car t cells for treating haematological malignancies there is a rapid growing interest in developing car engineered nk car nk cells for cancer therapy.